Effects of Cell Density and Cell Adhesion on Mitotic Nuclear Migration from a 3D Dynamic Cellular Finite Elements Model (3dDyCelFEM)

Cell division plays important roles in tissue growth. In pseudostratified epithelia, each cell nucleus migrates apically to facilitate planar-oriented division. density and adhesion between cells are known be two factors that control the migration of nucleus. We have constructed a biomechanical model investigate mechanism upward The cytoplasm is modeled as different 3D viscoelastic bodies following generalized Maxwell equations. derive equations motion formulate Dynamic Cellular Finite Element Model (3dDyCelFEM). Our test system consists center six surrounding cells. first study effects on by examining its shape speed. then strength migration. Results quantifying these reported.